With respect to recessively inherited disorders, why might it be a bad idea to marry your first cousin

Marrying your first cousin is a bad idea for many reasons, and especially when considering recessively inherited disorders. Recessive genetic disorders are caused by two copies of an abnormal gene from both parents. When it comes to recessively inherited diseases, there is a 25% chance that the children will be affected if the parents have just one copy each of the gene causing the disorder. If both parents carry two copies of this same recessive gene however, then the odds increase to 100%, meaning all their children will suffer from the disorder in question.

With respect to recessively inherited disorders, why might it be a bad idea to marry your first cousin

When cousins marry, they share many of the same genes due to their close relation. This increases their probability of having similar recessive alleles and therefore increases their risk of producing offspring with genetic disorders or other congenital abnormalities due to these shared genes. In fact, according to a 2017 study conducted by Durham University, married first cousins were three times more likely than unrelated couples to have handicapped children when compared side-by-side.
The most common examples of such recessive diseases include cystic fibrosis (CF), hereditary hearing loss, Tay-Sachs disease and Duchenne muscular dystrophy (DMD). These disorders often cause severe disability or suffering even leading up to premature death in some cases. For instance CF affects around 1 in every 2,000 babies born worldwide while DMD affects approximately 1 out 10000 boys across different countries around the world and causes progressive muscle degeneration resulting in difficulty walking as early as age 4-5 years old; eventually leading up to premature death due to respiratory failure between 16-25 years old on average if not treated properly and timely with medical care/therapy interventions .

Cousin marriage can also lead to an increased rate of consanguineous marriage within communities which further amplifies any underlying risks associated with genetic inheritance linked health conditions due reduced diversity in terms off new “non shared” alleles being introduced into subsequent generations through these marriages but mix marriages instead ; hence why it could potentially be far more beneficial for individuals living in communities where intermarriages take place – like some parts India & Pakistan – that they look beyond blood relations when choosing future life partners since this will help limit proliferation and spread off such rare but serious health issues linked back directly or indirectly towards consanguineous unions over time .

Additionally , First Cousins face higher risks during pregnancy too coupled along with chances off miscarriages & birth defects which can potentially endanger mother’s own life too e specially since data shows instances where newborns weight less than 500 grams at birth have been reported among consanguineous couples multiple times throughout history; prompting various nations / countries across globe like UK & USA ban partnerings between near relatives altogether given elevated likelihood offspring coming out off such unions may inherit any form simultaneous physical / mental / psychological related medical complications pertaining genetically inherited illnesses .

To conclude , marrying your first cousin carries numerous potential risks including those associated with hereditary diseases; ultimately making it a bad idea overall . While it’s possible for healthy kids come out from such unions provided necessary preventive measures are taken proactively prior conception without fail yet still primary motive must remain safeguarding well being off both would be parents plus baby before anything else so no unnecessary harm should arrive upon them down line later on due preventable circumstances either now or after few years post childbirth respectively

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